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Infect Immun. 1998 Jan;66(1):361-3.

Extensive immunoglobulin binding of Plasmodium falciparum-infected erythrocytes in a group of children with moderate anemia.

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Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden.


Immunoglobulins (Ig) from healthy, nonimmune individuals bind to the surfaces of Plasmodium falciparum-infected erythrocytes (RBC). In order to investigate the presence of this parasite phenotype in wild isolates and its potential association with malarial anemia, we conducted a study of 207 anemic or nonanemic children with malaria in Gabon. Surface Ig binding to infected RBC was detected for 83% of the isolates. No difference in Ig binding between the groups was observed, but all isolates which exhibited extensive Ig binding were found in a group of moderately anemic children.

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