Format

Send to

Choose Destination
See comment in PubMed Commons below
J Nucl Cardiol. 1994 Sep-Oct;1(5 Pt 1):457-76.

Antibody imaging in the evaluation of cardiovascular diseases.

Author information

1
Bouvé College of Pharmacy and Health Sciences, Northeastern University, Boston, MA 02115, USA.

Erratum in

  • J Nucl Cardiol 1994 Nov-Dec;1(6):585.

Abstract

Antimyosin antibody was originally developed for in vivo detection of acute myocardial infarction. However, its utility has expanded to include diagnosis of various cardiovascular diseases in which myocyte necrosis constitutes an obligatory component of the disease. Thus antimyosin has also been used clinically for noninvasive diagnosis of acute myocarditis, heart transplant rejection, drug-induced cardiotoxicity, and other cardiomyopathies. This first-generation monoclonal antibody, antimyosin, has opened the way for the second-generation monoclonal antibodies such as antifibrin and antiplatelet for in vivo diagnostic use in the detection of deep venous thrombosis and pulmonary embolism and antiatherosclerotic lesion-specific antibody for diagnosis of metabolically active lesions. Whether the third generation of antibodies will include ultrasmall antigen-binding units or negative charge-modified antibodies must await future studies.

PMID:
9420730
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center