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J Virol. 1998 Jan;72(1):767-71.

Molecular and immunophenotypical characterization of a feline immunodeficiency virus (FIV)-associated lymphoma: a direct role for FIV in B-lymphocyte transformation?

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1
Department of Veterinary Pathology, University of Glasgow, Bearsden, United Kingdom. J.Beatty@udcf.gla.ac.uk

Erratum in

  • J Virol 1998 Mar;72(3):2564.

Abstract

We describe the histopathological, immunohistochemical, and molecular characterization of a lymphoma arising in a 7-year-old cat following experimental infection with feline immunodeficiency virus (FIV). The tumor was high grade and of B-cell lineage. The transformed cell had an immature phenotype (CD79a+, CD79b-, CD21-, immunoglobulin heavy and light chain negative), confirmed by antigen receptor gene analysis, which showed germ line configuration. Single-copy, clonally integrated FIV provirus was detected in tumor genomic DNA. FIV p24 antigen was not detected in tumor cells by immunostaining. This study provides the first evidence that the feline lentivirus may play a direct role in cell transformation under certain circumstances.

PMID:
9420284
PMCID:
PMC109433
[Indexed for MEDLINE]
Free PMC Article
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