Format

Send to

Choose Destination
J Mol Evol. 1998 Jan;46(1):37-44.

Synonymous and nonsynonymous substitutions in mammalian genes: intragenic correlations.

Author information

1
Laboratoire de Génétique Moléculaire, Institut Jacques Monod, 2 Place Jussieu, 75005 Paris, France.

Abstract

Previous investigations indicated that synonymous and nonsynonymous substitution rates are correlated in mammalian genes. In the present work, this correlation has been studied at the intragenic level using a dataset of 48 orthologous genes from species belonging to at least four different mammalian orders. The results obtained show that the intragenic variability in synonymous rates is correlated with that of nonsynonymous rates. Moreover, the variation in GC level (and especially of C level) of silent positions along each gene is correlated with the variation in synonymous rate. These results reinforce the previous conclusions that synonymous and nonsynonymous rates as well as GC levels of silent positions are to some extent under common selective constraints.

PMID:
9419223
DOI:
10.1007/pl00006281
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center