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J Infect Dis. 1998 Jan;177(1):133-45.

Susceptibility to leprosy is linked to the human NRAMP1 gene.

Author information

1
INSERM Unité 436, Hôpital-Pitié Salpêtrière, Paris, France.

Abstract

Leprosy is a debilitating infectious disease of human skin and nerves. Genetic factors of the host play an important role in the manifestation of disease susceptibility. The human NRAMP1 gene is a leprosy susceptibility candidate locus since its murine homologue Nramp1 (formerly Lsh/Ity/Bcg) controls innate resistance to Mycobacterium lepraemurium. In this study, 168 members of 20 multiplex leprosy families were genotyped for NRAMP1 alleles and 4 closely linked polymorphic markers. Highly informative haplotypes overlapping the NRAMP1 gene were constructed, and the haplotype segregation into leprosy-affected offspring was analyzed. It was observed that the segregation of NRAMP1 haplotypes into affected siblings was significantly nonrandom. This finding is consistent with the hypothesis that NRAMP1 itself is a leprosy susceptibility locus.

PMID:
9419180
DOI:
10.1086/513830
[Indexed for MEDLINE]

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