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Fertil Steril. 1997 Dec;68(6):1097-102.

Control of human luteal steroidogenesis: role of growth hormone-releasing hormone, vasoactive intestinal peptide, and pituitary adenylate cyclase-activating peptide.

Author information

1
Institute of Obstetrics and Gynecology, Università Cattolica del Sacro Cuore, Rome, Italy.

Abstract

OBJECTIVE:

To examine the possible effect of growth hormone-releasing hormone (GHRH), vasoactive intestinal peptide, and pituitary adenylate cyclase-activating peptide on basal and hCG-stimulated P production by human luteal cells.

DESIGN:

Cultures of human luteal cells from the early and midluteal phase.

SETTING:

All corpora lutea were obtained from the Obstetrics and Gynecology Department of the Università Cattolica, a public care center.

PATIENT(S):

Ten nonpregnant women between 35 and 47 years of age underwent surgery for various nonendocrine disorders, such as leiomyomatosis.

INTERVENTION(S):

Corpora lutea were obtained at the time of hysterectomy.

MAIN OUTCOME MEASURE(S):

Luteal cells were incubated with GHRH, vasoactive intestinal peptide, and pituitary adenylate cyclase-activating peptide with or without hCG at different concentrations.

RESULT(S):

Pituitary adenylate cyclase-activating peptide stimulated P production in a dose- and time-dependent manner, whereas GHRH and vasoactive intestinal peptide did not affect luteal steroidogenesis. None of the three peptides were found to synergize with hCG.

CONCLUSION(S):

Pituitary adenylate cyclase-activating peptide can influence human luteal steroidogenesis.

PMID:
9418704
DOI:
10.1016/s0015-0282(97)00370-1
[Indexed for MEDLINE]

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