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Trends Biotechnol. 1997 Dec;15(12):487-94.

G-protein-coupled receptors in Saccharomyces cerevisiae: high-throughput screening assays for drug discovery.

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1
Cyanamid Agricultural Research Center, American Cyanamid Company, Princeton, NJ 08543-0400, USA. pauschm@pt.cyanamid.com

Abstract

G-protein-coupled receptors are an important class of therapeutic drug targets by virtue of their roles in the regulation of diverse cellular functions. Recent advances in the expression of heterologous G-protein-coupled receptors in the yeast Saccharomyces cerevisiae have led to the development of sensitive and selective assays of their ligand-induced activation. Implementation of this new technology in the high-throughput screening of compound libraries has enabled the discovery of novel ligands for the G-protein-coupled somatostatin receptor. This article describes the broad applicability of the technology and its use in drug discovery.

PMID:
9418303
DOI:
10.1016/S0167-7799(97)01119-0
[Indexed for MEDLINE]
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