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FEMS Microbiol Lett. 1997 Dec 1;157(1):201-5.

Amplification of bacitracin transporter genes in the bacitracin producing Bacillus licheniformis.

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Biotechnical Faculty, Department of Biology, University of Ljubljana, Slovenia.


We have amplified the previously cloned and sequenced genes of the bacitracin exporter (bcr), a member of the ATP-binding transport protein family, within the chromosome of the bacitracin producing Bacillus licheniformis. Amplification of the transporter genes was followed by greatly increased bacitracin resistance. Antibiotic production was enhanced at a low level of bcr genes amplification. An enlarged increase in the copy number of the bcr genes negatively affects the overall growth of bacteria.

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