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Exp Cell Res. 1997 Nov 25;237(1):7-13.

The tumor suppressor protein p16INK4a.

Author information

1
Department of Immunology and Oncology, Centro Nacional de Biotecnología, CSIC, Madrid, Spain. mserrano@cnb.uam.es

Abstract

The tumor suppressor protein p16INK4a (inhibitor of CDK4) is one of the most direct links between cell-cycle control and cancer. The p16INK4a gene is frequently inactivated in human tumors, and inheritance of mutant alleles results in susceptibility to several types of cancer. p16INK4a is part of a cell-cycle regulatory pathway that converges in the tumor suppressor protein Rb. The mechanisms that regulate p16INK4a are starting to be characterized.

PMID:
9417860
DOI:
10.1006/excr.1997.3824
[Indexed for MEDLINE]

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