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Exp Cell Res. 1997 Nov 25;237(1):1-6.

The retinoblastoma protein pathway in cell cycle control and cancer.

Author information

1
Institute of Cancer Biology, Danish Cancer Society, Copenhagen, Denmark.

Abstract

Recent discoveries in diverse fields of biomedical research have merged to reveal the molecular basis of cell cycle control and a critical role of subverting this homeostatic mechanism in cancer development. At the heart of these processes lies a late G1 checkpoint governed by the "RB pathway" whose molecular composition, functions, and cancer-associated defects are briefly evaluated in this review. This exciting new knowledge raises a plethora of conceptual issues in cell biology, with potential practical implications for biotechnology and medicine.

PMID:
9417859
DOI:
10.1006/excr.1997.3776
[Indexed for MEDLINE]

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