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Arthritis Rheum. 1997 Dec;40(12):2207-11.

A promoter polymorphism of tumor necrosis factor alpha associated with systemic lupus erythematosus in African-Americans.

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The Children's Hospital of Philadelphia, University of Pennsylvania, 19104, USA.



The polymorphic tumor necrosis factor alpha (TNFalpha) gene encodes a cytokine involved in inflammation, angiogenesis, and apoptosis. One polymorphic variant is associated with increased production of TNFalpha. This study examined the frequency of this polymorphic variant in African-American patients with systemic lupus erythematosus (SLE) compared with controls.


We determined the gene frequency of the polymorphic variant of TNFalpha in an African-American SLE patient population and in a geographically matched African-American control population.


The gene frequency of the TNFalpha -308A polymorphism was higher in the African-American SLE population than in the control population. This relationship was independent of major histocompatibility complex DR alleles.


The TNFalpha -308A polymorphism is associated with an increased risk of SLE in African-Americans.

[Indexed for MEDLINE]

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