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Mol Med Today. 1995 Sep;1(6):270-7.

Comparative protein modeling by satisfaction of spatial restraints.

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  • 1Rockefeller University, New York, NY 10021-6399, USA.


Approximately one third of known protein sequences are related to at least one known protein structure. As a result, an order of magnitude more sequences can be modeled by comparative modeling than there are experimentally determined protein structures. A large fraction of these models has an accuracy approaching that of a low resolution X-ray structure or a medium resolution nuclear magnetic resonance structure. The number of applications where homology modeling has been proven useful is growing rapidly.

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