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J Med Chem. 1997 Dec 5;40(25):4079-88.

Nonsymmetrically substituted cyclic urea HIV protease inhibitors.

Author information

1
DuPont Merck Pharmaceutical Company, Experimental Station, Wilmington, Delaware 19880-0500, USA.

Abstract

A series of nonsymmetrically substituted cyclic ureacarboxamides was synthesized and evaluated for antiviral activity as a function of the inhibition of HIV-protease. Selected protease inhibitors were also evaluated for oral bioavailability. The synthesis, pharmacology, quantitative structure-activity relationship (QSAR), and pharmacokinetics for the series will be discussed.

PMID:
9406598
DOI:
10.1021/jm970288b
[Indexed for MEDLINE]

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