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Nat Struct Biol. 1997 Dec;4(12):983-5.

The lymphoproliferation mutation in Fas locally unfolds the Fas death domain.

Abstract

NMR studies of the lymphoproliferation mutant (V238N) of the Fas death domain indicate that helix 3 is unfolded. This local structural change abolishes binding to FADD--a protein that interacts with Fas and also contains a death domain--and causes the accumulation of autoreactive T cells.

PMID:
9406545
[Indexed for MEDLINE]

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