Send to

Choose Destination
Eur J Clin Microbiol Infect Dis. 1997 Oct;16(10):747-50.

Longitudinal study of Aspergillus fumigatus strains isolated from cystic fibrosis patients.

Author information

Laboratoire des Aspergillus, Institut Pasteur, Paris, France.


The colonization over time of cystic fibrosis patients by Aspergillus fumigatus was investigated using a DNA fingerprinting method. Aspergillus fumigatus isolates collected sequentially for more than one year from six patients with cystic fibrosis were typed by Southern blot hybridization with a repetitive DNA sequence. Each cystic fibrosis patient harbored several strains of Aspergillus fumigatus that were isolated recurrently over time. Isolates collected from a cystic fibrosis patient with aspergilloma displayed the same genotype, suggesting that the infection was due to a single strain. Continuous isolation of the same genotype in another cystic fibrosis patient, however, was not correlated clinically with an Aspergillus infection.

[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center