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J Mol Biol. 1997 Dec 5;274(3):291-302.

Three-dimensional structures of proteins involved in programmed cell death.

Author information

1
Pharmaceutical Discovery Division, Abbott Laboratories, 100 Abbott Park Road, IL 60064, USA.

Abstract

Programmed cell death (apoptosis) is a controlled process by which unwanted cells are selectively eliminated. Several families of proteins including the Bcl-2, tumor necrosis factor receptor 1, and caspase families play essential roles in the regulation, signaling, and execution of the genetic cell death program. The recently described three-dimensional structures of members of these families elucidate the structural basis of their functions and provide insights into the mechanisms by which these proteins regulate apoptosis.

PMID:
9405139
DOI:
10.1006/jmbi.1997.1415
[Indexed for MEDLINE]
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