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Immunopharmacology. 1997 Oct;37(2-3):185-90.

Superoxide generation by monocytes following infection with human cytomegalovirus.

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Section of Serology, Institute of Immunological Science, Hokkaido University, Sapporo, Japan.


A significant level of superoxide (O2-) generation was observed in a U937-derived subclone following infection with human cytomegalovirus (HCMV). Although there were no detectable levels of viral mRNA and/or protein expression, HCMV DNA content transiently increased immediately before O2- generation. Similarly, O2- generation was also observed in peripheral blood monocytes derived from healthy donors.

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