Format

Send to

Choose Destination
Trends Microbiol. 1997 Nov;5(11):447-50.

Why are hepadnaviruses DNA and not RNA viruses?

Author information

1
Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 19111, USA. c_seeger@fccc.edu

Abstract

Virion assembly in hepadnaviruses is a two-step process leading to (1) the packaging of viral pregenomic RNA and reverse transcriptase into nucleocapsids and (2) the assembly of nucleocapsids with envelope components, which results in the formation of mature virus particles. Characteristically, both steps are intimately coupled to viral DNA synthesis. While assembly of nucleocapsids is coupled to the protein priming of reverse transcription, virion formation is linked to genome maturation.

PMID:
9402701
DOI:
10.1016/s0966-842x(97)01141-4
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center