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Trends Microbiol. 1997 Nov;5(11):440-6.

How rolling circle plasmids control their copy number.

Author information

1
CFSAN Divn of Microbiological Studies, US Food and Drug Administration, Washington, DC 20204, USA. axr@vm.cfsan.fda.gov

Abstract

Rolling circle DNA replication is inherently continuous and unregulated. This 'go-for-broke' strategy works well for lytic phages but is suicidal for plasmids that must coexist with their host. Plasmids have consequently evolved elaborate copy number control systems that operate at the transcriptional, translational and post-translational levels.

PMID:
9402700
DOI:
10.1016/S0966-842X(97)01143-8
[Indexed for MEDLINE]

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