Format

Send to

Choose Destination
See comment in PubMed Commons below
Environ Health Perspect. 1997 Sep;105 Suppl 5:1069-72.

Susceptibility of p53-deficient mice to induction of mesothelioma by crocidolite asbestos fibers.

Author information

1
Department of Pathology and Laboratory Medicine, Brown University School of Medicine, Providence, RI 02912, USA.

Abstract

Exposure of mesothelial cells to asbestos fibers in vitro has been shown to induce DNA damage mediated by oxidants. An early cellular response to DNA damage is increased expression of the p53 protein. This protein induces transcription of genes that activate cell cycle checkpoints or induce apoptosis. A murine mesothelial cell line that spontaneously acquired a point mutation in the p53 gene shows increased sensitivity to DNA damage induced by crocidolite asbestos fibers. It is hypothesized that p53-deficient mice will show increased sensitivity to the genotoxic effects of asbestos and accelerated development of malignant mesotheliomas.

PMID:
9400702
PMCID:
PMC1470134
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for PubMed Central
    Loading ...
    Support Center