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J Clin Invest. 1997 Dec 15;100(12):3014-8.

Immunization against the agent of human granulocytic ehrlichiosis in a murine model.

Author information

1
Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA.

Abstract

The agent of human granulocytic ehrlichiosis (HGE) is a newly recognized tick-borne pathogen that resides within polymorphonuclear leukocytes. C3H/HeN mice can become infected with the agent of HGE (designated aoHGE) by syringe inoculation or tick-borne infection and develop transient neutropenia. They thereby partially mimic human disease and provide a model in which to study immunity to this microorganism. Mice vaccinated with lysates of purified aoHGE, or administered aoHGE antisera, were partially protected from both syringe- and tick-transmitted challenge with aoHGE. These data suggest that antibodies are sufficient to provide substantial, but not complete, immunity against aoHGE.

PMID:
9399947
PMCID:
PMC508513
DOI:
10.1172/JCI119855
[Indexed for MEDLINE]
Free PMC Article

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