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Hepatology. 1997 Dec;26(6):1667-77.

Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver.

Author information

1
Department of Medicine, University Hospital, Z├╝rich, Switzerland.

Abstract

The Na+-dependent bile salt uptake systems Ntcp (rodents) and NTCP (human), and the Na+-independent organic anion transporters oatpl (rat) and OATP (human) mediate sinusoidal uptake of a variety of amphipathic organic compounds into hepatocytes. Their properties indicate that an overall hepatic clearance of albumin-bound compounds is mediated by a limited number of multispecific transporters with partially overlapping substrate specificities.

PMID:
9398014
DOI:
10.1002/hep.510260641
[Indexed for MEDLINE]

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