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Trends Biochem Sci. 1997 Nov;22(11):413-6.

A CTD function linking transcription to splicing.

Author information

1
Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. jeff_corden@qmail.bs.jhu.edu

Abstract

Since its discovery in 1985, the function of the C-terminal domain (CTD) of RNA polymerase II has been a puzzle. Recent studies suggest that the CTD functions as a linear platform for assembly of complexes that splice, cleave and polyadenylate pre-mRNA. A new set of CTD-associated SR-like proteins (CASPs) have been implicated in pre-mRNA processing and transcription elongation as a component of the emerging 'transcriptosome'.

PMID:
9397679
DOI:
10.1016/s0968-0004(97)01125-0
[Indexed for MEDLINE]

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