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J Forensic Sci. 1997 Nov;42(6):1183-5.

Tissue distribution of ketamine in a mixed drug fatality.

Author information

1
Armed Forces Institute of Pathology, Division of Forensic Toxicology, Rockville, MD, USA. moore@email.afip.osd.mil

Abstract

While reports of ketamine abuse are increasing, reports of ketamine deaths and tissue concentrations associated with fatalities are rare. We report here a case of a mixed drug fatality involving ketamine and ethanol. Ketamine analysis was carried out by gas chromatography with a nitrogen-phosphorus detector (NPD). We found the following tissue concentrations: blood 1.8 mg/L; urine 2.0 mg/L; brain 4.3 mg/kg; spleen 6.1 mg/kg; liver 4.9 mg/kg, and kidney 3.6 mg/kg. The blood ethanol concentration was 170 mg/dL. Because an empty nalbuphine ampule was found in the possession of the deceased, the blood was assayed for this opioid compound using a gas chromatography/mass spectrometry (GC/MS) method. None was detected at a limit of detection of 0.02 mg/L.

PMID:
9397567
[Indexed for MEDLINE]

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