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FEBS Lett. 1997 Nov 3;417(1):85-8.

The macrophage migration inhibitory factor MIF is a phenylpyruvate tautomerase.

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1
Department of Pharmacology, University of Lund, Sweden.

Abstract

A macrophage migration inhibitory factor (MIF), originally described as a product of activated lymphocytes, has been defined as a 12 kDa protein, expressed in a wide variety of tissues. Here MIF is identified as a phenylpyruvate tautomerase (EC 5.3.2.1) having p-hydroxyphenylpyruvate and phenylpyruvate as its natural substrates. The definition of MIF as an enzyme may yield insight into the mechanism of action of this proinflammatory and immunomodulating cytokine.

PMID:
9395080
DOI:
10.1016/s0014-5793(97)01261-1
[Indexed for MEDLINE]
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