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FEBS Lett. 1997 Nov 3;417(1):1-5.

Alu sequences.

Author information

1
Molecular Medicine Unit, The University of Leeds, St. James's University Hospital, UK. A.J.Mighell@leeds.ac.uk

Abstract

Alu sequences are frequently encountered during study of human genomic nucleic acid and form a major component of repetitive DNA. This review describes the origin of Alu sequences and their subsequent amplification and evolution into distinct subfamilies. In recent years a number of different functional roles for Alu sequences have been described. The multiple influences of Alu sequences on RNA polymerase II-mediated gene expression and the presence of Alu sequences in RNA polymerase III-generated transcripts are discussed.

PMID:
9395063
DOI:
10.1016/s0014-5793(97)01259-3
[Indexed for MEDLINE]
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