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Eur J Immunol. 1997 Nov;27(11):2835-9.

Cloning of NKG2-F, a new member of the NKG2 family of human natural killer cell receptor genes.

Author information

1
Human Immunogenetics Laboratory, Imperial Cancer Research Fund, London, GB. plougast@icrf.icnet.uk

Abstract

The NKG2 family of genes encodes at least four different type II transmembrane molecules (NKG2-A, NKG2-B, NKG2-C and NKG2-E) which contain a C-lectin domain. These proteins have been shown to be covalently associated with CD94, another C-type lectin member. The heterodimers are involved in natural killer cell-mediated recognition of different HLA-allotypes. Here we describe the cloning of a new NKG2-related gene, termed NKG2-F, localized 25 kb from NKG2-A as well as its relationship with the previously described NKG2-D cDNA. Despite the similarities with the other NKG2 genes, NKG2-F encodes a putative protein which does not contain any lectin domain. However, a conserved 24-amino acid sequence, present in all members of the NKG2 family, suggests that NKG2-F is also able to form heterodimers with CD94.

PMID:
9394807
DOI:
10.1002/eji.1830271114
[Indexed for MEDLINE]

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