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J Psychosom Res. 1997 Nov;43(5):529-34.

Acute phase proteins in major depression.

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Department of Psychology, Faculty of Medicine, University of the Witwatersrand, Republic of South Africa.


Extensive evidence exists associating depression with changes in the immune system. The present study evaluates the levels of complement components C3 and C4, C-reactive proteins, and IL-6 in patients who met DSM-III-R diagnostic criteria for major depressive disorder, as well as controls. Whereas no significant differences between the mean levels of C3 could be detected between depressed patients and controls, the levels of C4, IL-6 (where detected), and C-reactive protein were significantly raised in the group with a depressive disorder. Our study suggests an interaction between psychological state and immune systems operative in host defenses.

[Indexed for MEDLINE]

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