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Peptides. 1997;18(9):1441-4.

Inhibition of bacterial growth by synthetic SP-B1-78 peptides.

Author information

1
Department of Pediatrics, University of California, San Francisco, USA. mkaser@sfghpeds.ucsf.edu

Abstract

Residues 12-34 of mature human pulmonary surfactant protein B (SP-B1-78) are 68% homologous to residues 48-72 of the frog peptide antibiotic dermaseptin b I. We examined the effects of SP-B1-78 on the growth of Escherichia coli in order to find whether full length SP-B1-78 might act as a peptide antibiotic. We found that SP-B1-78 peptide inhibited growth of E. coli (MIC = 210 micrograms.ml-1), but that the SP-B variant [R/K-->S]SP-B1-78 was less potent (MIC = 500 micrograms.ml-1).

PMID:
9392848
DOI:
10.1016/s0196-9781(97)00211-8
[Indexed for MEDLINE]

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