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Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13499-503.

Ultraspiracle: an invertebrate nuclear receptor for juvenile hormones.

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1
School of Biological Sciences, Molecular and Cellular Biology Section, University of Kentucky, Lexington, KY 40506, USA.

Abstract

Juvenile hormones (JH), a sesquiterpenoid group of ligands that regulate developmental transitions in insects, bind to the nuclear receptor ultraspiracle (USP). In fluorescence-based binding assays, USP protein binds JH III and JH III acid with specificity, adopting for each ligand a different final conformational state. JH III treatment of Saccharomyces cerevisiae expressing a LexA-USP fusion protein stabilizes an oligomeric association containing this protein, as detected by formation of a protein-DNA complex, and induces USP-dependent transcription in a reporter assay. We propose that regulation of morphogenetic transitions in invertebrates involves binding of JH or JH-like structures to USP.

PMID:
9391054
PMCID:
PMC28334
[Indexed for MEDLINE]
Free PMC Article

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