Format

Send to

Choose Destination
See comment in PubMed Commons below
Pac Symp Biocomput. 1996:331-49.

Puzzle pieces defined: locating common packing units in tertiary protein contacts.

Author information

  • 1Duke University Medical Center, Biochemistry Dept., Durham, NC 27710, USA.

Abstract

Puzzle pieces are defined as small packing units which make up the unique tertiary interactions in proteins. Anti-parallel and perpendicular helix-helix contacts were broken down into basic puzzle-piece pairs in order to study the traits of such contacts: their limited geometry, preferred residue involvement, residue conformation and other common constraints. These traits can then be used for continued comparison of other protein structures, improving models of and designing proteins de novo and, in time, predicting 3D structure from primary sequence. Results from a small (100 proteins) database of anti-parallel helix-helix contacts and from preliminary work on a large database (600 proteins) of perpendicular helix-helix contacts are presented.

PMID:
9390242
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Pacific Sympsium On Biocomputing
    Loading ...
    Support Center