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Fertil Steril. 1997 Nov;68(5):927-30.

Low-dose aspirin for oocyte donation recipients with a thin endometrium: prospective, randomized study.

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  • 1Reproductive Science Center of the Bay Area Fertility and Gynecology Medical Group, San Ramon, California, USA.

Abstract

OBJECTIVE:

To evaluate the effect of low-dose aspirin use in oocyte donation recipients with an endometrial thickness of < 8 mm.

DESIGN:

A prospective, randomized study.

SETTING:

An oocyte donation program in a private infertility practice.

PATIENT(S):

Twenty-eight recipients undergoing oocyte donation who failed to develop an endometrial thickness of at least 8 mm in a previous evaluation cycle.

INTERVENTION(S):

Fifteen recipients received low-dose aspirin (81 mg/d) in addition to standard hormone replacement for an oocyte donation cycle. The remaining 13 recipients did not receive aspirin.

MAIN OUTCOME MEASURE(S):

Clinical pregnancy rates, delivery rates, implantation rates, and change in endometrial thickness were compared in the aspirin and nonaspirin groups.

RESULT(S):

There was no demonstrable increase in endometrial thickness in the aspirin-treated group. However, there was a statistically significant increase in implantation rates in the aspirin-treated group (24% versus 9%) and in implantation rates and clinical pregnancy rates in the aspirin-treated group when the final endometrial thickness was < 8 mm.

CONCLUSION(S):

Low-dose aspirin therapy improves implantation rates in oocyte donation recipients with a thin endometrium.

Comment in

PMID:
9389827
[PubMed - indexed for MEDLINE]
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