Format

Send to

Choose Destination
Curr Opin Genet Dev. 1997 Oct;7(5):628-33.

Early steps in vertebrate cardiogenesis.

Author information

1
National Institute for Medical Research, Ridgeway, Mill Hill, London, UK. t-mohun@nimr.mrc.ac.uk

Abstract

Heart formation provides an excellent model for studying the molecular basis of cell determination in vertebrate embryos. By combining molecular assays with the experimental approaches of classic embryology, a model for the cell signalling events that initiate cardiogenesis is emerging. Studies of chick, amphibian, and fish embryos demonstrate the inductive role of dorso-anterior endoderm in specifying the cardiac fate of adjacent mesoderm. A consequence of this signalling is the onset of cardiomyogenesis and several transcription factors--Nkx2-5-related, HAND, GATA and MEF-2 families--contribute to these events.

PMID:
9388779
DOI:
10.1016/s0959-437x(97)80010-x
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center