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J Biol Chem. 1997 Dec 5;272(49):30607-10.

STAT3 acts as a co-activator of glucocorticoid receptor signaling.

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Department of Cell Biology, Pulmonary Division, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.


Interleukin-6 (IL-6) and glucocorticoids are important mediators of inflammatory and immunological responses. Glucocorticoids are known to synergistically enhance IL-6-mediated cellular responses. We now show that IL-6 also has a synergistic effect upon glucocorticoid signaling. In particular, IL-6-activated STAT3 associates with ligand-bound glucocorticoid receptor to form a transactivating/signaling complex, which can function through either an IL-6-responsive element or a glucocorticoid-responsive element. These findings reveal a new level of interaction between these two crucial signaling cascades and indicate that activated STAT3 can also act as a transcriptional co-activator without direct association with its DNA binding motif.

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