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Chem Biol. 1995 Oct;2(10):645-9.

In the clutches of proteoglycans: how does heparan sulfate regulate FGF binding?

Author information

1
Department of Pathology, University of Wisconsin, Madison 53706, USA.

Abstract

Fibroblast growth factors and their receptors bind to heparan sulfate glycosaminoglycans. This is thought to promote ligand-receptor binding and enhance signaling by promoting receptor multimerization. Synthetic mimetics designed to occupy these binding sites may provide the means to understand and to regulate FGF signaling.

PMID:
9383470
DOI:
10.1016/1074-5521(95)90025-x
[Indexed for MEDLINE]
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