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Chem Biol. 1995 Oct;2(10):633-8.

Let's get specific: the relationship between specificity and affinity.

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  • 1NeXstar Pharmaceuticals, Inc., Boulder, CO 80301, USA.


The factors that lead to high-affinity binding are a good fit between the surfaces of the two molecules in their ground state and charge complementarity. Exactly the same factors give high specificity for a target. We argue that selection for high-affinity binding automatically leads to highly specific binding. This principle can be used to simplify screening approaches aimed at generating useful drugs.

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