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Chem Biol. 1995 Aug;2(8):503-8.

New insights into proteasome function: from archaebacteria to drug development.

Author information

1
Harvard Medical School, Department of Cell Biology, Boston, MA 02115, USA.

Abstract

The proteasome is not simply a 'garbage disposal unit' but also has functions in the control of the cell cycle and immune responses. The structure of an archaebacterial proteasome has recently been determined to high resolution, and provides insight into the unusual mechanism of proteolytic cleavage by the proteasome.

PMID:
9383453
DOI:
10.1016/1074-5521(95)90182-5
[Indexed for MEDLINE]
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