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Ann Neurol. 1997 Oct;42(4):670-3.

Idiopathic torsion dystonia linked to chromosome 8 in two Mennonite families.

Author information

1
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX, USA.

Abstract

The DYT1 locus on chromosome 9q34 is responsible for most childhood limb-onset idiopathic torsion dystonia (ITD). Linkage to DYT1 has been excluded in families with adult-onset, and predominantly cranial-cervical, ITD. We mapped a locus (DYT6) associated with prominent cranial-cervical ITD in two large Mennonite families to chromosome 8. An identical haplotype spanning 40-cM segregates with ITD in these families, suggesting a shared mutation from the recent past.

PMID:
9382482
DOI:
10.1002/ana.410420421
[Indexed for MEDLINE]

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