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Cell Tissue Res. 1997 Oct;290(1):1-10.

GAL4-responsive UAS-tau as a tool for studying the anatomy and development of the Drosophila central nervous system.

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Institut für Genetik, Universität Mainz, Saarstr. 21, D-55122 Mainz, Germany.


To improve the quality of cytoplasmic labelling of GAL4-expressing cells in Drosophila enhancer-trap and transgenic strains, a new GAL4-responsive reporter UAS-tau, which features a bovine tau cDNA under control of a yeast upstream activation sequence (UAS), was tested. Tau, a microtubule-associated protein, is distributed actively and evenly into all cellular processes. Monoclonal anti-bovine Tau antibody reveals the axonal structure of the labelled cells with detail similar to that of Golgi impregnation. We demonstrate that the UAS-tau system is especially useful for studying processes of differentiation and reorganisation of identified neurones during postembryonic development.

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