Format

Send to

Choose Destination
See comment in PubMed Commons below
Neuroreport. 1997 Sep 8;8(13):2931-5.

Presence of NF-kappaB-like and IkappaB-like immunoreactivities in postsynaptic densities.

Author information

1
Department of Neuroplasticity, Research Center on Aging and Adaptation, Shinshu University School of Medicine, Matsumoto, Japan.

Abstract

The distributions of IkappaB and NF-kappa B immunoreactivities were examined immunohistochemically in the rat brain by the electron microscopy. Antibodies were raised against synthetic peptides with the sequences specific to the human MAD-3 type IkappaB or NF-kappa B. Both IkappaB alpha and NF-kappa B immunoreactivities were localized in the dendrites including the spines and, particularly, the postsynaptic densities (PSDs) of the hippocampus and the cerebral cortex. The PSD fraction prepared from the rat brain contained an activity that inhibited the binding of NF-kappa B to the kappa B DNA elements. These results suggest that the NF-kappa B/IkappaB system or a similar mechanism may play a role in signal transmission from synapses to the nucleus.

PMID:
9376533
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wolters Kluwer
    Loading ...
    Support Center