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J Rheumatol. 1997 Nov;24(11):2221-4.

Elevated levels of hyaluronic acid in the sera of women with fibromyalgia.

Author information

1
Department of Rheumatology, Souraski Tel Aviv Medical Center, Tel Aviv University Sackler School of Medicine, Israel.

Abstract

OBJECTIVE:

To evaluate serum levels of hyaluronic acid (HA) in patients with fibromyalgia (FM).

METHODS:

HA serum levels were evaluated by a radiometric assay in 42 women with FM (ACR criteria), 27 female patients with rheumatoid arthritis (RA) and 36 healthy female controls matched for age.

RESULTS:

HA serum levels (mean microg/l +/- SEM) were 41 +/- 8.7 in healthy controls; 113 +/- 15.9 in RA: and 420 +/- 26 in FM.

CONCLUSION:

HA serum levels in women with FM were significantly elevated compared to healthy controls and patients with RA. This observation suggests that FM is associated with a biochemical abnormality and that serum HA could be a laboratory marker for its diagnosis.

PMID:
9375887
[Indexed for MEDLINE]

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