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J Perinatol. 1997 Sep-Oct;17(5):383-8.

Alteration of normal gastric flora in neonates receiving ranitidine.

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1
Division of Neonatology, Children's Hospital, Omaha, Neb., USA.

Abstract

OBJECTIVES:

To determine if the administration of ranitidine to neonates leads to an increase in gastric pH to > or = 4 and if this increase in gastric pH correlates with gastric colonization.

STUDY DESIGN:

628 pH measurements and 276 gastric cultures were obtained from 86 neonates. Twenty-three patients received ranitidine and 63 patients served as controls.

RESULTS:

Treated patients had a mean gastric pH of 5.6 compared with a control mean pH of 4.4 (p < 0.0001). Gastric pH was significantly affected by feeding and postnatal age. 54 patients were colonized with pathogenic bacteria and/or yeast (n = 20 treated, n = 34 control). Length of hospitalization (p < 0.0001), increase in gastric pH (p < 0.01), days of antibiotics before culture (p < 0.0001), and ranitidine use (p < 0.0001) were associated with an increased rate of colonization.

CONCLUSIONS:

The use of ranitidine did lead to a significant increase in gastric pH and with this increase in gastric pH gastric colonization rates increased. No increased frequency of infection was found in ranitidine-treated infants.

PMID:
9373844
[Indexed for MEDLINE]

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