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Horm Metab Res. 1997 Sep;29(9):417-21.

GLP-1 (7-36) amide: effects on glucose transport and metabolism in rat adipose tissue.

Author information

1
Department of Metabolism, Nutrition and Hormones, Foundación Jiménez Díaz, Madrid, Spain.

Abstract

In rat adipocytes, GLP-1 (7-36) amide induced an increment in 2-deoxy-glucose uptake, which was additive to that of insulin. Furthermore, in rat fat, GLP-1 (7-36) amide provoked a rise in glycogen synthesis, glucose oxidation and utilization and lipogenesis, the increments being lower than those obtained with insulin. These data support the idea that GLP-1 exerts insulin-like effects on glucose metabolism in rat adipose tissue, as it does in rat hepatocytes and skeletal muscle, although with a lower potency than that of insulin.

PMID:
9370107
DOI:
10.1055/s-2007-979068
[Indexed for MEDLINE]

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