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Brain Res Dev Brain Res. 1997 Oct 20;103(1):91-3.

Adrenal steroids suppress granule cell death in the developing dentate gyrus through an NMDA receptor-dependent mechanism.

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Laboratory of Neuroendocrinology, Rockefeller University, New York, NY 10021, USA.


Treatment with the NMDA receptor antagonist MK-801 prevented the adrenal steroid-induced suppression of cell death, determined by both morphological identification of pyknotic cells and TUNEL staining, in the dentate gyrus in rat pups. This finding suggests that adrenal steroids naturally promote granule cell survival via NMDA receptor activation.

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