Format

Send to

Choose Destination
Brain Res Dev Brain Res. 1997 Oct 20;103(1):91-3.

Adrenal steroids suppress granule cell death in the developing dentate gyrus through an NMDA receptor-dependent mechanism.

Author information

1
Laboratory of Neuroendocrinology, Rockefeller University, New York, NY 10021, USA. goulde@princeton.edu

Abstract

Treatment with the NMDA receptor antagonist MK-801 prevented the adrenal steroid-induced suppression of cell death, determined by both morphological identification of pyknotic cells and TUNEL staining, in the dentate gyrus in rat pups. This finding suggests that adrenal steroids naturally promote granule cell survival via NMDA receptor activation.

PMID:
9370064
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center