Preparation, antimicrobial evaluation, and mutagenicity of [2-hydroxyaryl]-[1-methyl-5-nitro-1H-2-imidazolyl]methanols , [5-tert-butyl-2-methylaminophenyl]-[1-methyl-5-nitro-1H-2-imidazo lyl]me thanol, and [2-hydroxyaryl]-[1-methyl-5-nitro-1H-2-imidazolyl] ketones

Bioorg Med Chem. 1997 Oct;5(10):1959-68. doi: 10.1016/s0968-0896(97)00138-7.

Abstract

Efficient preparations of the titled compounds are described, their antimicrobial activity and mutagenic properties being evaluated. Some of the studied compounds are nonmutagenic and present a MIC as low as some of the usual standards in the field.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Infective Agents / chemical synthesis*
  • Anti-Infective Agents / pharmacology*
  • Ketones / chemical synthesis*
  • Ketones / pharmacology*
  • Methanol / analogs & derivatives*
  • Microbial Sensitivity Tests
  • Mutagenicity Tests
  • Nitroimidazoles / chemical synthesis*
  • Nitroimidazoles / pharmacology*
  • Structure-Activity Relationship

Substances

  • Anti-Infective Agents
  • Ketones
  • Nitroimidazoles
  • Methanol