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Pharmacol Res. 1997 Jul;36(1):55-7.

The effect of chronic stress on hepatic and gastric lipid peroxidation in long-term depletion of glutathione in rats.

Author information

1
Department of Biochemistry, Istanbul Faculty of Medicine, University of Istanbul, Turkey.

Abstract

The effect of chronic stress (immobilization and cold) on hepatic and gastric thiobarbituric acid reactive substances (TBARS) and vitamin C levels were investigated in rats having long-term depletion of glutathione (GSH) by applying buthionine sulfoximine (BSO). GSH and vitamin C levels decreased and TBARS levels increased in the liver and stomach of rats subjected to stress. Long-term BSO administration along with stress caused no additional changes in these parameters. These results may indicate that long-term glutathione depletion did not potentiate stress-induced hepatic and gastric lipid peroxidation.

PMID:
9368915
DOI:
10.1006/phrs.1997.0204
[Indexed for MEDLINE]

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