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Pharmacol Res. 1997 Jul;36(1):55-7.

The effect of chronic stress on hepatic and gastric lipid peroxidation in long-term depletion of glutathione in rats.

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Department of Biochemistry, Istanbul Faculty of Medicine, University of Istanbul, Turkey.


The effect of chronic stress (immobilization and cold) on hepatic and gastric thiobarbituric acid reactive substances (TBARS) and vitamin C levels were investigated in rats having long-term depletion of glutathione (GSH) by applying buthionine sulfoximine (BSO). GSH and vitamin C levels decreased and TBARS levels increased in the liver and stomach of rats subjected to stress. Long-term BSO administration along with stress caused no additional changes in these parameters. These results may indicate that long-term glutathione depletion did not potentiate stress-induced hepatic and gastric lipid peroxidation.

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