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Curr Opin Immunol. 1997 Oct;9(5):702-8.

Prospects for adoptive T cell therapy.

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  • 1Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA.


Since the establishment of methods to isolate genes encoding cytotoxic T lymphocyte defined tumor antigens, several antigens have been identified and characterized for suitability as target antigens for immunotherapy. The development of innovative strategies to generate T cells targeting these antigens and lessons learned from clinical trials of adoptive immunotherapy of viral diseases should facilitate the design of clinical trials for specific adoptive immunotherapy of cancer.

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