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Diagn Microbiol Infect Dis. 1997 Oct;29(2):103-6.

In vitro antifungal activity of novel azole derivatives with a morpholine ring, UR-9746 and UR-9751, and comparison with fluconazole.

Author information

1
Department of Medicine, Santa Clara Valley Medical Center, San Jose, CA 95128-2699, USA.

Abstract

Thirty-three patient fungal isolates were studied by broth macrodilution methods for susceptibility to novel azole derivatives with a morpholine ring, UR-9746 and UR-9751, and fluconazole. MICs (micrograms/ml) ranged widely, but none had lower MICs for Candida albicans or Cryptococcus neoformans than UR-9751. Fluconazole and UR-9751 had the most activity versus other Candida species. Activity was demonstrated versus endemic fungal pathogens. Aspergillus species were generally resistant, although modest activity was seen. UR-9746 and UR-9751 are active in vitro, with a potency comparable to that of fluconazole.

PMID:
9368086
DOI:
10.1016/s0732-8893(97)00104-1
[Indexed for MEDLINE]

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