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The Drosophila neurogenic gene big brain, which encodes a membrane-associated protein, acts cell autonomously and can act synergistically with Notch and Delta.
Development. 1997 Oct;124(19):3881-93. doi: 10.1242/dev.124.19.3881.
Development. 1997.
PMID: 9367444
Drosophila big brain does not act as a water channel, but mediates cell adhesion.
Tatsumi K, Tsuji S, Miwa H, Morisaku T, Nuriya M, Orihara M, Kaneko K, Okano H, Yasui M.
Tatsumi K, et al.
FEBS Lett. 2009 Jun 18;583(12):2077-82. doi: 10.1016/j.febslet.2009.05.035. Epub 2009 May 23.
FEBS Lett. 2009.
PMID: 19467350
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