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J Am Acad Dermatol. 1997 Nov;37(5 Pt 1):734-9.

Merkel cell carcinoma: analysis of clinical, histologic, and immunohistologic features of 132 cases with relation to survival.

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1
Laboratory Corporation of America, Herndon, Virginia, USA.

Abstract

BACKGROUND:

Merkel cell carcinoma (MCC) is an uncommon malignancy of the skin and has a high rate of recurrence and metastasis. There have been few large studies of the biologic behavior of MCC.

OBJECTIVE:

Our purpose was to determine whether there were clinical or histologic features of MCC that predict its biologic behavior.

METHODS:

We reviewed 132 cases of MCC. Clinical and histologic features were correlated with follow-up information to determine whether any of these were associated with prognosis.

RESULTS:

Clinical information was available on 126 patients; 57 were alive, 1 was alive with tumor, 28 died of tumor, 27 died from other causes, and 14 were lost to follow-up. MCC on the buttock/thigh area or trunk had the worst prognosis, and those on the distal extremities had the best prognosis; however, the difference was not statistically significant. Sex and age were not significant factors. Small cell size, high mitotic rate, and large tumor size were associated with a low survival rate. When cell size was excluded, male sex and depth of invasion were associated with a worse survival, although these were not statistically significant.

CONCLUSION:

Cell size, mitotic rate, and tumor size are significant factors in relation to the biologic behavior of MCC.

PMID:
9366819
[Indexed for MEDLINE]
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